Beilstein J. Org. Chem.2018,14, 106–113, doi:10.3762/bjoc.14.6
reactions using a mixture of nucleophiles (for directsubstitutions) and aryls (for Friedel–Crafts reactions) to give products 5–9. The nucleophilic substitution reactions of 1 are shown in Table 1 and Table 2, and were all conducted using either a mixture of water/isopropanol, or tris(hydroxymethyl)propane
PDF
Graphical Abstract
Figure 1:
C–F activation of benzylic fluorides to generate benzylamine or diarylmethane products.
Beilstein J. Org. Chem.2011,7, 866–877, doi:10.3762/bjoc.7.99
substitutions on propargylic (allylic, benzylic) alcohols, with various nucleophiles (and bi-nucleophiles) based on the σ- and/or π-acidity of gold(III) complexes. Synthetic developments are also briefly described.
Keywords: directsubstitutions; gold; isoxazolines; propargylic substitutions; Introduction
In
Olivier Debleds Eric Gayon Emmanuel Vrancken Jean-Marc Campagne Institut Charles Gerhardt, UMR 5253, Equipe AM2N, ENSCM 8 rue de l’Ecole Normale, 34296 Montpellier Cédex, France 10.3762/bjoc.7.99 Abstract This personal account summarizes our recent developments in gold-catalyzed direct